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At the same time, other works have reported opposing results, describing no association between this mutation and the aggressiveness of PTC (–). Despite discrepancies and controversies, the opinion that the BRAFV600E genetic alteration is a marker of aggressiveness in this type of tumor is becoming stronger, as is the idea that this mutation should be used in a clinical setting as molecular determinant for more radical treatments. Exploring the extensive literature on the subject, we have noticed that most studies addressing this issue have analyzed the frequency of the BRAFV600E mutation in histologically heterogeneous populations of thyroid carcinomas among which the distantly metastatic and fatal cases were quite underrepresented (). Therefore, very little information is currently available on the correlation between BRAFV600E mutation and the most significant factor of poor PTC prognosis, namely the development of distant metastases. 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